Endocrine Abstracts

Aim: There is a significant link between the increased activity of estrogen and its metabolites in endometrial carcinogenesis. Polymorphisms of the gene involved in metabolism of estrogen can modulate risk for the development of endometrial cancer. CYP1B1 plays an important role in estrogen metabolism. In our study, the frequency of three CYP1B1 gene polymorphisms (4326 C> G, 4390 A> G and 355 G> T) were studied in obese and non-obese women with endometrio...

Introduction: Merkel cell carcinoma is a rare and aggressive neuroendocrine skin cancer. It is characterized by a high rate of local recurrence after surgical resection as well as the occurrence of distant metastases. It mostly occurs in the elderly and the exact etiology is unknown. The most significant risk factors for its occurrence are exposure to ultraviolet light and the oncogenic effect of the Merkel cell polyoma virus.Aim: Demographic and clinica...

Aim: Functional neuroendocrine tumors (NETs) represent a specific diagnostic and therapeutic challenge. Hormonal clinical syndrome can severely complicate clinical picture and affect treatment. Functional pancreatic NETs have been extensively studied. Our aim was to analyze functional lung NETs in terms of clinical characteristics and survival.Materials and methods: We retrospectively analyzed data from 230 patients with lung NETs treated at our departme...

Paragangliomas (PGLs) and pheochromocytomas (PCCs) are rare neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic neural ganglia, respectively. We retrospectively analyzed 82 patients (43 female and 38 males) predominantly with PGLs who were hospitalized between January 2002 and December 2022. Twenty one patients were lost to follow up. The median age at diagnosis was 47 years (11–75) and the mean tumor size was ...

Background: Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to androgen excess in these women. Therefore, the aim of the present study was to examine the association of adiponectin levels and androgens in women with PCOS.Methods: A total of 60 women with PCOS who met the 2003 Rotterdam ...